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Molecules, 30 (1), Article 50

Chrysis D, Calikoglu AS, Ye P, DErcole AJ: Insulin-like growth factor-I overexpression attenuates cerebellar apoptosis by altering the expression of Bcl family proteins in a developmentally specific manner

Because of this rapid degradation, it was widely believed that oral glutathione had extremely poor bioavailability (often estimated at less than 5%) and could not effectively raise systemic intracellular stores

However, artificial overexpression of IGF-1R in vitro does result in malignant transformation ( TP53, BRCA1 , von-Hippel Lindau protein and Wilms tumour-1 (Werner, 2012)