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In several breast cancer cell lines, metformin induces ferroptosis via different mechanisms, such as inhibiting UFMylation of SLC7A11 and targeting the miR-324-3p/GPX4 axis, suggesting another potential anti-cancer property of metformin (48, 49)

References Dohmen, R

New England Journal of Medicine , 360 (24), 2528-2535

Biol Rhythm Res 53(7):10431057 Onseng K, Johns NP, Khuayjarernpanishk T, Subongkot S, Priprem A, Hurst C, Johns J (2017) Beneficial effects of adjuvant melatonin in minimizing oral mucositis complications in head and neck cancer patients receiving concurrent chemoradiation

Since pyocyanin expression and biofilm formation could be rescued with an exogenous antioxidant addition, PmtA likely controls the transcription of the genes involved in pyocyanin expression by altering the redox environment