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Co-administration of 300 mg/kg of l-carnitine plus 10 mg/kg of olmesartan could control doxorubicin-induced (20 mg/kg) cardiotoxicity in rats, through elevation of cardiac levels of glutathione and superoxide dismutase and reduction of cardiac levels of malondialdehyde, transforming growth factor Beta, NF-kB, myeloperoxidase, Interleukin IL-1, intercellular adhesion molecules-1, tumor necrosis factor-alpha and caspase-3 [84]

doi: 10.1186/S12917-016-0676-X 31 GallerAISuchodolskiJSSteinerJMSungCHHittmairKMRichterBet al

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Thereby, the intestinal epithelial cells are destroyed, and damage to the intestinal mucosal barrier results in inflammatory bowel disease