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Its prevalence increases significantly with age, rendering it the principal cause of blindness globally, responsible for approximately 48% of blindness cases [35]

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Their ability to migrate, proliferate, and secrete ECM is essential for effective dermal tissue regeneration 69

We previously succeeded in identifying human ACF in situ using magnifying colonoscopy with methylene blue staining, and showed that the number of rectal ACF increased in a stepwise fashion from normal subjects to adenoma patients, and then to cancer patients, suggesting that ACF are precursor lesions to the adenomacarcinoma sequence in humans 13, 14

Depending on the peptide in question, they can signal the body to repair tissue, reduce inflammation, or modulate function