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L-Carnitine can be synthesized by humans, but only if the starting materials lysine and methionine, as well as the relevant cofactors vitamin C, vitamin B6, B12, niacin, folic acid and iron, are sufficiently available

338,339 In contrast, patients with T1DM often benefit from insulin therapy regarding neuropathic outcomes, as they typically do not exhibit significant insulin resistance

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635 Human bodies primarily use the alpha-tocopherol form of vitamin E, and alpha-tocopherol is necessary to treat vitamin E deficiency