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However, this study had no control group, a small sample, and no standardized diagnosis

The third thing that often is overlooked, which really shapes our environment, which has really reframed my paradigm

Physiol Rev 87:245313 Zhang W, Xiao D, Mao Q, Xia H (2023) Role of neuroinflammation in neurodegeneration development

Effectively targeting these non-LDL-C pathways is a central challenge in current lipid-lowering therapy

A subgroup analysis from the meta-analysis, however, found that the Leu allele was significantly associated with risk in African Americans, using either an additive (odds ratio = 1.91, 95% confidence interval [CI]: 1.023.58) or recessive (odds ratio = 2.09, 95% CI: 1.163.76) model, suggesting the need for additional studies, as the numbers of cases in this subgroup were small (173)