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In a mouse model, supplementation with VD induces an anti-inflammatory phenotype in macrophages and exhibits anti-proliferative properties (123)

Yes, it does

None of the major metabolites were associated with hepatotoxic, carcinogenic, immunotoxic, mutagenic, or cytotoxic risks, corroborating their safety for human use

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On one hand, to sustain rapid proliferation, cancer cells actively reprogram iron metabolism pathways by upregulating iron import proteins such as TFR1 and DMT1, while downregulating the FPN, thereby increasing intracellular Fe + uptake, which in turn promotes mitochondrial function, DNA synthesis, and cell cycle progression (84)