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Furthermore, hypoxia activates peripheral chemoreceptors, causing hyperventilation, hypercapnia, cerebral vasoconstriction, and hypoperfusion, thereby worsening cognitive impairment [358, 359]

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The accumulation of cholesterol and fats along the walls of arteries can cause a decreased blood flow and oxygen supply to the heart, brain, and other organs

Second, they suggested a new categorization model for mild depression recognition

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