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Nanodelivery co-delivery system (NDCDS) allows two active substances to be encapsulated in the same nanocarrier, delivered simultaneously to the tumor site, and released in a designed ratio and time sequence, resulting in synergistic effects within the tumor cells (255)

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Los efectos secundarios comunes incluyen, pero pueden no estar limitados a: dolor o enrojecimiento en el sitio de inyeccin diarrea leve prurito (picazn) hinchazn aumentada dolor en las articulaciones mareo dolor de cabeza nerviosismo o ansiedad Efectos secundarios graves pueden incluir: reacciones alrgicas trombosis vascular perifrica hipokalemia (bajos niveles de potasio) edema pulmonar (acumulacin de lquido alrededor o en los pulmones) trombocitosis insuficiencia cardaca congestiva Se han reportado casos de shock anafilctico y muerte tras la administracin parenteral de vitamina B12

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