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These haemichromes are extremely hazardous and may initiate the production of ROS, including hydroxyl radicals, thereby causing oxidative damage in erythroid cells (Matte and De Franceschi, 2019)

Histological examination of liver tissue plays a crucial role in confirming the diagnosis, excluding alternate or comorbid etiologies, distinguishing AIH from ASC/overlap syndrome, and assessing fibrosis stage for prognostication

Environ Exp Bot 56:8794 Baek KH, Skinner DZ (2003) Alteration of antioxidant enzyme gene expression during cold acclimation of near-isogenic wheat lines

We previously reported that in addition to its support of antioxidant function, the glutathione cycle also serves as a reservoir of intracellular neural glutamate (16)