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In 1985, she accepted a concurrent position at the National Cancer Institute of the NIH, Leidos Biomedical Research, where she is a Senior Principal Scientist and Principal Investigator heading the Computational Structural Biology Section at the NCI

In turn, the elevated IGF2BP3 protein stabilizes c-Myc mRNA and interferes with c-Myc protein degradation, creating a self-reinforcing circuit that amplifies and sustains the expression of both oncogenes [57]