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For these organs, GSH from the blood circulation will be first cleaved by -glutamyl transpeptidase (-GT) to yield glutamate and cysteinylglycine

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On the other hand, adipocytes subjected to oxidative stress express distress factors which are subsequently identified by the cluster of differentiation 8 (CD8), lymphocytes as well as natural killer cells (NK) which will synthesize interferon- (IFN-) inducing the transition of adipose tissue macrophages from the anti-inflammatory (M2) state to the pro-inflammatory (M1) state triggering inflammation [16]