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morning and night) or at least once daily (commonly at bedtime)

Clinical progression of ocular injury following arsenical vesicant lewisite exposure

Couzin, J

Copper serves as an essential cofactor for over a dozen so-called cuproenzymes, including superoxide dismutase (SOD) for antioxidant defense, lysyl oxidase for collagen cross-linking, and cytochrome c oxidase for cellular respiration