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Finally, a network meta-analysis incorporating data from 50 randomized placebo-controlled trials involving approximately 20,000 AD patients demonstrated that the administration of melatonin (3 mg/day) over a period of 6 to 12 months was associated with improved cognitive function [226]

doi: 10.1371/journal.pbio.3001480 195 MaekawaTSasaokaTAzumaSIchikawaTMelroseHLFarrerMJet al