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Homologous regulation of melanocortin-1 receptor (MC1R) expression in melanoma tumor cells in vivo

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1 h pretreatment, 4 h/24 h tracer incubation) engages PHGDH in MDA-MB-468 cells, reducing glucose-derived serine synthesis, impairing one-carbon unit incorporation into nucleotides from both endogenous and exogenous serine, and increasing SHMT1-mediated one-carbon unit wasting

The BMDL value of E Cd computed at 5% BMR could be considered as the NOAEL equivalent or the level of exposure below which an effect of Cd on eGFR or E Pro was discernable [20,21,33]

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