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Melatonin protects the electron transport chain (ETC) by binding to the Fe-S cluster of NADPH dehydrogenase, reducing the generation of superoxide anion radicals (O2) caused by electron leakage, blocking the opening of the mitochondrial permeability transition pore (mPTP), and preventing apoptosis caused by cytochrome C leakage (Hardeland, 2017

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Moreover, mice given either fusion consistently demonstrated an increase in the plasma concentrations of insulin following the glucose challenge (Fig

Ven R, Castellani P, Delfino L, Lucibello M, Ciriolo MR, Rubartelli A

J., Abdel-Rehim, M