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R Clinical implications of slow acetylation: Increased risk of isoniazid-induced hepatotoxicity and peripheral neuropathy (tuberculosis treatment) R Increased risk of sulfonamide hypersensitivity reactions R Increased risk of aromatic amine-related bladder cancer in occupational exposure settings (dye workers, rubber industry) R Drug-induced lupus from hydralazine and procainamide occurs almost exclusively in slow acetylators R Altered caffeine metabolism (slow acetylators clear caffeine more slowly via the NAT2 pathway) R NAT1 polymorphisms are less well characterized but the slow allele NAT1*14 has been associated with increased risk of cancers from dietary aromatic amines

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[20] 2011 season [edit] Clemson took a major step forward in Hopkins's sophomore year, finishing with a 104 mark

Es stellt den entscheidenden Schutz der Zellund Mitochondrienmembranen vor der Schdigung durch reaktive Sauerstoffspezies (oxidativer Stress) dar

Since DEAB is not specific to ALDH1A1 and also inhibits other members of the ALDH-family of proteins [36], we validated our results by using shRNA specific to Aldh1a1 (Fig