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In the mouse model of epilepsy, GS is directly phosphorylated on threonine residue 301 (T301) within the enzymes active site by cAMP-dependent protein kinase (PKA) resulting in a dramatic decrease in glutamine synthesis along with enhanced T301 phosphorylation (Huyghe et al., 2019)

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Oncogene 22 , 256265 (2003)

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