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Pirfenidone selectively downregulates the expression of TGF-1, PDGF, and other fibrosis-associated cytokines, and nintedanib is a tyrosine kinase inhibitor targeting the VEGF receptor, FGF receptor, and PDGF receptor

Apart from stimulating immune responses via death-associated antigens, immunogenic cell death is accompanied by the release of diverse damage-associated molecular patterns (DAMPs), such as calreticulin (CRT), high mobility group protein 1 (HMGB1), adenosine triphosphate (ATP), heat shock proteins (HSPs), and others

[Google Scholar] [PubMed] [CrossRef] Bourgonje AR, von Martels JZH, de Vos P, Faber KN, Dijkstra G (2018)

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Actin dynamics underlie all processes in the cell involving mechanical functions