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Description

This research is preliminary

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ALRN-5281 is a 29-amino acid analog of human growth hormone-releasing hormone (GHRH) that may be clinically applicable in patients with growth hormone deficiency syndromes

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Severe side effects are rare but can include nerve injury or difficulty swallowing

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Hydrochloric acid and/or sodium hydroxide may have been added to adjust the pH (range 4.5-7.0)

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The results suggest that NNMT and 1-MNA reduce proteasome degradation of SIRT1 by reducing SIRT1 ubiquitination (55)

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