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In the case of esomeprazole at both 10 mg and 20 mg doses, adjusted S-CIT doses of 5 mg (reduction by 50%) and 7.5 mg (reduction by 25%) were recommended for G-EM and G-IM, respectively (Figure 5B)

Physiological expression of macrophage apoE in the artery wall reduces atherosclerosis in severely hyperlipidemic mice

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This is not counting the added expense of behavioural therapy, which is also often prescribed concomitantly with medication and contributes to the cost