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Description

10.1021/acs.chemrestox.6b00319

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Additionally, HIF-1 supports the maintenance of GSCs by upregulating stemness-associated genes such as KLF4, MYC, OCT4, SOX2, and NANOG, sustaining their self-renewal and resistance to conventional therapies

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Similarly, targeting other metabolic complexes or enzymes is restricted by their toxicity to normal tissues

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Glutathione acts as a buffer, ensuring the cells within the kidneys remain resilient

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