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Macro-B12 Elevated serum B12 can sometimes be due to a phenomenon called macro-B12, in which B12 forms complexes with immunoglobulins that accumulate in the blood due to reduced clearance

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Strongest human evidence The METAOD006 (OPTIONS) Phase 2b trial randomized 502 adults with obesity (BMI 30-45 kg/m^2) to oral AOD-9604 (0.25, 0.5, or 1 mg/day) or placebo for 24 weeks alongside a supervised diet and exercise program

Latest findings with homocysteine is that a high level of it is associated with cardiovascular diseases

Significance of optineurin mutations in glaucoma and other diseases