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Overall, there was a transient increase in serum creatinine observed within 10 days of dosing in 1.8% of Reclast-treated patients versus 0.8% of placebo-treated patients which resolved without specific therapy [see Warnings and Precautions (5.3)]

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Both multivitamins contain vitamin B12, but it is important to ensure that the form of B12 included in any multivitamin is methylated

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These drugs are either oxidative in nature or can generate oxidant compounds in the body, inducing oxidative stress to the RBCs leading to hemolysis