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(+)- tocopherol succinate (-TOS), a succinate ester of (+)- tocopherol, can induce apoptosis of NB4, NB4-R2 (ATRA-resistant) and primary APL cells

For the pathways using precursors that require a phosphoribosyl moiety, such as NAM and nicotinic acid (NA), PRPP is required 22

doi:10.1046/j.1432-1327.2000.01595.x Study: Oxidative stress in the brain contributes to cognitive decline, mitigated by glutathione

In contrast, FoB exhibit lower intracellular ROS and maintain a metabolic setup that is distinct from that in MZB

In the Wnt pathway, the key step of the Wnt pathway is the binding of the Wnt protein to the Frizzled receptor, and the nuclear redox protein (NRX) blocks Disheveled (DVL) and plays a negative regulatory role in the Wnt pathway (Yu et al., 2021)