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Considering the multifactorial pathogenesis of OA, future research needs to prioritize conducting early proof-of-concept clinical trials to evaluate the feasibility and synergistic effects of locally applied ferroptosis inhibitors such as Fer-1 or GPX4 activators combined with existing conservative treatments including weight management, physical therapy, and NSAIDs or emerging cell and tissue engineering therapies

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Avak vina vskumov v poslednch dvoch desaroiach dokzala, e plazmatick hladina redukovanho L-glutathionu, redukovanho glutathionu neme vykazova hladiny v inch tkanivch a redukovan L-glutathin, redukovan glutathin m perorlnu biologick dostupnos