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Acknowledgements We would like to acknowledge support from Fondos Federales (Grant number HIM 2019/029 SSA 1575)

Peptides Seg.Id.No: 2,3,4 and 6 were applied in the dosage 8, 25 and 50 mg/kg b.w., i.v

Our findings reveal an unexpected role for GPX2 in modulating pancreatic and hepatic cell fate decisions and provide insights into the intricate interplay between oxidative stress and cell fate determination during hPSC differentiation into endoderm derivatives, with emphasis on pancreatic endocrine cell development

26 H 2 O 2 is not a very oxidizing molecule but can yield the highly reactive hydroxyl radical (HO ) by reduction by metals (Fenton reaction) (eq 3) (Figure 1)