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Some reverse T3 is produced normally in the body, but is then rapidly degraded

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ATP levels in the hippocampus and prefrontal cortex of CUMS depression model mice were reduced, but injecting ATP into the lateral ventricle may significantly enhance their depressive behavior (Shen et al., 2020)

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For example, the IKK overexpression could suppress the insulin pathway, and IKK genetic deletion alleviated the course of insulin resistance in the obese animal model, such as HFD-induced and Lep ob/ob obese mice [108]