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Severe nausea requiring treatment discontinuation was rare in monotherapy trials, with only about 1% of participants in the REDEFINE 1 trial stopping treatment because of adverse events overall

Notably, caffeic acid phenethyl ester down-regulates the mdr-1 gene, which is considered responsible for the resistance of cancer cells to certain chemotherapeutic agents

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Data relating to the biological role of Sod3 in embryo development are still missing