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Considering the high cost of antibodies, present research has been focused on natural constituents with pharmacological activities that can also modulate Th17/Treg imbalances by regulating transcription factors (RORt, STAT3, Foxp3 and STAT5)

In the CTX- and D-galactose-exposed mouse model, the use of metformin is associated with improved serum hormonal levels and follicle numbers, exhibiting mTOR-inhibitory and anti-apoptotic effects (Huang et al., 2021)

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