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We recently documented the conserved autophagy function of AKAP11 in human neurons and demonstrated a critical role of AKAP11 in maintaining the homeostasis of PKA-RI protein complex in the soma and neurites through autophagy degradation 10

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This article explores the scientific evidence, clarifies when B12 supplementation might be associated with anxiety-like symptoms, and provides guidance on safe management aligned with UK clinical practice and NICE recommendations