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In addition, ACSL4 inhibition may ameliorate renal injury by decreasing the levels of lipid peroxidation products and inhibiting ferroptosis (123)

Therapeutic potential of synthetic and natural iron chelators against ferroptosis

For selectivity studies, recombinant GSTO1 (1 M), PDI (1 M), BSA (1 M) or GRP78 (1 M) in reaction buffer were incubated with C1-27 or DMSO for 30 min at 37 C, followed by incubation with CMFDA (500 nM), BODIPY- C1-27A (1 M) or DMSO for 30 min