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The increase in extracellular pH may also lead to impaired intestinal barrier integrity by disrupting microbial communities in the gut that are important regulators of overall gut homeostasis

Foller M, Kasinathan RS, Koka S, Lang C, Shumilina E, Birnbaumer L, et al

10.1016/j.bbi.2011.08.007 12

6 Conclusion In conclusion, oxidative stress is involved in AD pathophysiology, therefore there is a strong preclinical rationale to incorporate antioxidative agents, as adjuvant treatment, in the AD pharmacopeia