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Sex is a key variable in vascular biology and in particular, EC function is influenced by sexual hormones, but also by chromosomes resulting in sex-specific differences in gene expression profile

Nishimura N, Kaji K, Kitagawa K, et al

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10.1523/jneurosci.0713-04.2004 119 TolomeoS.SteeleJ

Through SA--gal staining, we found that FOXO4-DRI also reduced the number of positive cells in the aorta of D-galactose induced aged mice (Figure 2C)