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Abstract The establishment of mechanism-driven peripheral markers is important for translational psychiatry

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Mechanistic Research Perspective Disruption of FOXO4p53 protein interaction Activation of p53-mediated apoptosis pathways Modeling senescent cell survival and removal mechanisms Analysis of transcription-factor signaling networks Investigation of age-related cellular stress responses Primary Research Applications Cellular Senescence Studies: FOXO4-DRI is widely used in experimental models to investigate how senescent cells accumulate and influence tissue function

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To validate these results, we conducted additional experiments using a HaCaT cell inflammation model, which similarly showed the same reductions in the expression levels of TNF- , IL-1 , and IL-8 (Fig