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A key observation was the production of anti-cagrilintide antibodies, with increased incidence correlating with higher doses and prolonged exposure, affecting 46% to 73% of participants by week 26

There are studies supporting this theory, demonstrating a reduced GABA concentration in the CSF and in the cerebral cortex of patients with SPS

Grintescu IM, Luca Vasiliu I, Cucereanu Badica I, Mirea L, Pavelescu D, Balanescu A, Grintescu IC: The influence of parenteral glutamine supplementation on glucose homeostasis in critically ill polytrauma patientsa randomized-controlled clinical study