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Given that nearly the entire transcriptome can exhibit isoform switching under mTOR modulation, there is an urgent need for systematic investigations into the functional importance of specific isoforms in distinct biological contexts

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Nature 435: 839843 Guil S, Cceres JF (2007) The multifunctional RNAbinding protein hnRNP A1 is required for processing of miR18a

Moreover, HCC cells can produce lipids de novo while simultaneously increasing the absorption of fatty acids (FAs) [4]

Before making the diagnosis of PFIC, in the paediatric population, other cholestasis disorders should always be considered in the differential diagnosis, including biliary atresia, choledochal malformations, congenital endocrine disorders, inborn errors of metabolism (mainly during the neonatal period) as well as autoimmune liver diseases, drug-induced cholestasis and other genetic diseases in older children [72]