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Description

Among 38 identified hits, we found a subset of chloroacetamides with broad senolytic activity

Ectopic expression of the phospho-deficient CDH1-7A mutants that can bind to the APC/C core and are constitutively active 14 , induced a senescence-like state, indicative of an irreversible G0 state in both RB -proficient and RB -deficient BC cell lines (Fig