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The short answer: the ideal needle size for a B12 injection depends on the injection method

(Swaminathan et al., 2017), the X-ray crystal structure of a ternary complex of NNMT bound with MNAM was elucidated, revealing that MNAM binds to the active site of NNMT, thereby impeding NAM binding and suppressing NNMTs enzymatic activity

It is not classified as a controlled substance under UK law

I have self injected upper arms for the last three or so years now,Ive did hundreds of injections and the only time I feel pain is if Im lucky enough to have a nurses appointment,other than that I feel totally in control of any pain risks and although I admit I still hate doing them its not because its painful its just needle phobia in my case

[1] If a rash or generalized itching develops, the injection should be halted and the patient evaluated, as it could be a prodrome of a more serious reaction