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Ca 2+ signaling and/or ROS have been shown to contribute to eryptosis induced by cetyltrimethylammonium bromide-coated Au nanorods [454], self-assembling antimicrobial nanofibers [457], Fe 3 O 4 NPs [456], TiO 2 NPs [455], SOD-CAT-poly(lactic-co-glycolic acid) NPs [460], and dextran-polyacrylamide-embedded Ag NPs [461]

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Several studies have demonstrated that Nrf2 contributes to the anti-inflammatory process as well as increased cysteine production (needed to make glutathione for detoxing)

Elevated levels of cell surface PDK1 have been observed in aggressive cancer types, including lung cancer, gastric cancer, and myeloma (Wu et al., 2015)

Since taking lipoic acid with a meal decreases its bioavailability, it is generally recommended that lipoic acid be taken 30 min prior to a meal (see also Metabolism and Bioavailability) (8)