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Although these therapies are often discussed together, they work through very different biological pathways

Because unbound drug concentration is determined by dosing rate and clearancewhich is not altered, in the case of these low-extraction-ratio drugs, by protein bindingincreases in dosing rate will cause corresponding changes in the pharmacodynamically important unbound concentration

Stacks discussed are for experimental design

Nuclear Magnetic Resonance Proton and carbon NMR can help confirm the quinolinium ring, methyl group and amino-substitution pattern

That conclusion must remain within the mouse experiment