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Diabetes Care 34 , 22202224 (2011)

Optimal dosing varies based on individual factors including body weight, body composition goals, and metabolic responsiveness

National Institutes of Health lists the characteristics of B12 deficiency as: megaloblastic anemia (abnormally large and immature red blood cells) fatigue constipation loss of appetite neurological issues, such as difficulty with balance, depression, and confusion Certain people might also be more likely to need a vitamin B12 supplement: If youre vegan or vegetarian If you follow a vegetarian or vegan diet, youre at a higher risk of a vitamin B12 deficiency since meat, eggs, poultry, and other dairy animal products are the main sources of B12

As levels continue to drop, symptoms become more noticeable

This is determined by the presence of a molecule called the intrinsic factor that is essential for the absorption of B12 into your system