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These changes correlate with increased GSH levels and decreased ACSL4 expression, thus mitigating ferroptotic cell death in IL-1stimulated chondrocytes and preserving cartilage integrity (187)

In addition, supplement with vitamin C could mitigate MIA-induced OA in rats [160]

To test the functional involvement of M2 macrophages in fibrotic pathology, we first induced macrophage polarization in vitro by using LPS or IL-4 into either M1 or M2 phenotypes, respectively (Additional file 1: Figure S3)

In contrast, increased cell death was consistently observed across various lymphoid cell types, including tumor cells, underscoring that, within 3D gels, cell death, rather than cell cycle arrest, impedes lymphoid cell growth