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A three-year randomized, double-blind, placebo-controlled trial in 818 older adults (aged 50-70 years) with elevated homocysteine levels but normal serum vitamin B 12 levels found that folic acid supplementation (800 g/day) lowered homocysteine levels and improved measures of memory performance (115)

Some studies demonstrated the indirect regulation of ferroptosis via DNA and protein methylation

Treated animals show increased oxygen consumption and energy expenditure measured by indirect calorimetry, confirming enhanced metabolic rate

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