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Dopaminergic therapies such as levodopa, dopamine agonists, and monoamine oxidase B (MAO-B) inhibitors provide meaningful relief, particularly during the early stages of the disease, but their efficacy wanes over time [5]

The tryptophan 5-hydroxylase 1, crucial for the synthesis of serotonin (5-HT), and tyrosine hydroxylase, a rate-limiting enzyme in the production of dopamine, adrenaline, and noradrenaline, are both positively regulated by SCFAs (175, 176)

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As a conclusion, ozone treatment seems to have a beneficial effect on RBCs