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Certain patients on GLP-1 medications have experienced acute pancreatitis or even cancer

NAD+ reduction hampers PARP1's function, which is a key enzyme that spots and attaches to broken DNA strands to start repair processes

Think of it as flipping a switch on fat cells that tells them to release their contents

This potential is precisely why the FDA granted priority review for orforglipron's application and why the medical community watches its development with unusual intensity