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Paeonol (Pae) upregulates FOXO3 by inhibiting the expression of miR-155, thereby preventing the proliferation induced by TNF- and the release of cytokines in RAM model, with weakened the generation of IL-6 and IL-1 (64)

Through the N-ethyl-N-nitrosourea (ENU) mutagenesis protocol in mice, it was reported that Slc4a10, encoding solute carrier family 4, sodium bicarbonate transporter, member 10, is a novel late-onset hearing loss gene, critical to inner ear homeostasis [37]