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Increased excretion of mast cell mediator metabolites during mast cell activation syndrome

Superoxide dismutase (SOD) enzyme helps convert O 2 to hydrogen peroxide (H 2 O 2 )

1 H-NMR (DMSO-d6) spectral data of [Se(Vit E) 2 (His)(Cl)(H 2 O)] complex (Scheme 1) = 0.742, 0.767, 0.968, 1.070, 1.142, 1.889, 1.957, 3.084 (50 protons of 8CH 3 , 11CH 2 and 3CH groups), 7.303 (proton of OH group of vit E), and 7.514, 7.621, 7.738 (NH 2 and aromatic imidazole ring of His moiety)

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Targeting critical pathways such as CXCR2 signaling and neutrophil-derived inflammatory mediators may offer effective strategies for managing acute gout attacks and preventing progression toward chronic tophaceous disease