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In contrast, XO can produce ROS using O 2 as a terminal electron acceptor [19]

This makes adhering to the treatment plan simpler and increases the compliance of patients who are taking care of their diabetes, providing a sustained therapeutic effect with fewer doses

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Clin Nucl Med 44:452458 Lugano R, Ramachandran M, Dimberg A (2020) Tumor angiogenesis: causes, consequences, challenges and opportunities

Carmeliet G Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188