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Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial

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SARS-CoV-2 ORF3a blocked the fusion of autophagosomes with lysosomes To investigate whether ORF3a abolished the fusion of autophagosomes with lysosomes, autophagic flux assays were conducted by measuring the localization and intensity of the fusion protein mCherry-GFP-LC3